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红细胞生成素(Epo)是调节红系晚期祖细胞存活、增殖和分化的主要生长因子。Epo通过结合细胞表面特异的红细胞生成素受体(Epo-R)而发挥功能。Epo可激活多条信息通路,且多条信息通路之间又有信息交谈(crosstalk)。体现了Epo-R介导的信号转导的复杂性和特异性。
Epo (erythropoietin) is a major growth factor that regulates the survival, proliferation and differentiation of erythroid progenitor cells. Epo functions by binding to cell-surface-specific erythropoietin receptor (Epo-R). Epo activates multiple message paths and crosstalk between multiple message paths. Reflects the complexity and specificity of Epo-R-mediated signal transduction.