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Notch信号通路在脊椎动物和无脊椎动物中高度保守,它在决定细胞的分化上起重要作用。Notch信号通路由受体、配体和核效应物三部分组成。它对正常心血管系统的发育有重要作用,Notch信号表达不足或者过量都会造成动物因心血管异常而死亡。正常情况下,Notch信号抑制胚胎干细胞向心肌细胞的分化。此外,Notch信号在动静脉分化中也具有重要作用,它能促进前体细胞向动脉细胞发育。
The Notch signaling pathway is highly conserved in vertebrates and invertebrates and plays an important role in determining the differentiation of cells. Notch signaling pathway by the receptor, ligand and nuclear effect of three parts. It has an important role in the development of the normal cardiovascular system, and insufficient or excessive Notch signaling can cause death in animals due to cardiovascular abnormalities. Normally, Notch signaling inhibits the differentiation of embryonic stem cells into cardiomyocytes. In addition, Notch signaling also plays an important role in arteriovenous differentiation, which promotes the development of precursor cells into arterial cells.