论文部分内容阅读
目的研究盐酸普萘洛尔(PNH)的肠吸收情况,为制剂合理选择处方和临床药代动力学与药效学的深入研究奠定基础。方法采用大鼠单向灌流模型,引入了重量法来标示灌流液体积。考察药液浓度和pH值对肠吸收的影响。结果 PNH在全肠道均有良好的吸收,且吸收不受药物浓度和pH值的影响。结论可以考虑将PNH制成匀速释放的剂型。
Objective To study the intestinal absorption of propranolol hydrochloride (PNH) and lay the foundation for the rational selection of prescriptions and clinical pharmacokinetics and pharmacodynamics. Methods One-way rat perfused rat model was used, and the gravimetric method was used to indicate the volume of perfusate. Investigate the concentration of liquid and pH on intestinal absorption. Results PNH had good absorption in the whole intestine, and the absorption was not affected by drug concentration and pH value. Conclusions A dose form of PNH can be considered for uniform release.