3-氯-4-氟硝基苯系合成抗菌剂诺氟沙星(norfloxacin)等吡喹酮类药物的重要中间体,也是制备高效,低毒农药“除草醚”的起始原料。其需求量日益增大。为此,各国学者对其合成方法和工艺路线进行了改进,虽然收率有所提高,但反应温度高,氟化钾配 3-Chloro-4-fluoronitrobenzene is an important intermediate for the synthesis of praziquantel, such as norfloxacin, as an antibacterial agent. It is also the starting material for the preparation of a highly effective and low toxic pesticide “weedicide”. Its demand is increasing day by day. To this end, scholars from various countries have made improvements to their synthesis methods and process routes. Although the yield has been raised, the reaction temperature is high, potassium fluoride