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目的探讨职业性慢性二硫化碳中毒的远期效应。方法以35名退休的职业性慢性轻度二硫化碳中毒患者为观察组,另35名非有毒有害岗位退休人员为对照组,观察分析观察组临床症状、体征的转归,观察两组在血压、血脂、心电图、B超上的差异及高血压病、糖代谢异常、急性冠脉综合征、脑卒中的发病情况。结果观察组随诊时乏力、头痛、失眠、多梦、易怒、健忘、膝腱反射减弱或消失发病率分别为34.2%、71.42%、82.86%、68.57%、28.57%、80.00%、54.29%,与诊断时比较差异均有统计学意义(均P<0.01);头昏、健忘、双手麻木、双下肢麻木、手颤、双下肢肌肉震颤、手套、袜套样感觉障碍、跟腱反射减弱或消失发病率分别为88.57%、80.00%、37.14%、51.43%、11.43%、25.71%、100%、100%,与诊断时比较差异均无统计学意义(均P>0.05)。观察组的脂肪肝、高血压病、糖代谢异常、急性冠脉综合征、脑卒中发病率分别为45.72%、74.29%、37.14%、22.86%、28.57%,与对照组对比差异均有统计学意义(均P<0.05)。结论职业性慢性二硫化碳中毒的远期效应表现为中毒者的周围神经病变症状、体征无明显改善;而高血压病、脂质代异常、糖代谢异常、心脑血管疾病的发病率增高。
Objective To investigate the long-term effect of occupational chronic carbon disulfide poisoning. Methods 35 retired patients with occupational chronic mild carbon disulfide poisoning were selected as the observation group and 35 non-toxic and hazardous post retirees as the control group. The clinical symptoms and signs of the observation group were observed and analyzed. The changes of blood pressure, , ECG, B-up differences and hypertension, abnormal glucose metabolism, acute coronary syndrome, stroke incidence. Results The incidence of fatigue, headache, insomnia, dreaminess, irritability, forgetfulness and knee tendon reflexes in observation group were 34.2%, 71.42%, 82.86%, 68.57%, 28.57%, 80.00%, 54.29% (All P <0.01); dizziness, forgetfulness, numbness of both hands, numbness of both lower extremities, hand tremor, muscle tremor of both lower extremities, sensory disturbances of gloves and socks, weakening of Achilles tendon reflex or The incidence of disappearance was 88.57%, 80.00%, 37.14%, 51.43%, 11.43%, 25.71%, 100%, 100% respectively. There was no significant difference between the two groups (all P> 0.05). The incidence of fatty liver, hypertension, abnormal glucose metabolism, acute coronary syndrome and stroke in the observation group were 45.72%, 74.29%, 37.14%, 22.86% and 28.57%, respectively, which were statistically different from the control group Significance (all P <0.05). Conclusions Long-term effects of occupational chronic carbon disulfide poisoning are the symptoms of peripheral neuropathy of poisoning. There is no obvious improvement of symptoms. The incidence of hypertension, dyslipidemia, abnormal glucose metabolism and cardiovascular and cerebrovascular diseases are increased.