目的　用超低剂量内毒素给正常妊娠鼠注射 ,产生一种妊高征的动物模型。方法　在妊娠大鼠的第 14d ,尾静脉注射内毒素 (1.0ug·kg-1体重 ) ,并测量血压、尿蛋白。结果　内毒素注射组血压升高 ,尿蛋白含量明显增加 (P <0 0 5和P <0 0 1)。结论　妊娠大鼠静脉注射内毒素后可形成妊高征动物模型 Objective To inject normal endometriosis rats with ultra-low dose of endotoxin to produce an animal model of pregnancy-induced hypertension. Methods Endotoxin (1.0ug · kg-1 body weight) was injected into tail vein of pregnant rats on the 14th day, and blood pressure and urinary protein were measured. Results In the endotoxin injection group, blood pressure was increased and urinary protein content was significantly increased (P <0.05 and P <0.01). Conclusion Pregnant rats intravenous injection of endotoxin can form pregnancy induced hypertension animal model