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目的 探讨肝纤维化的血清学诊断指标。 方法 测定正常人30例和各种慢性肝病患者73例的血清脯氢酸肽酶(PLD)、Ⅲ型前胶原(PC Ⅲ)和透明质酸(HA)水平。 结果 PLD活性变化与ALT显著相关(r=0.4495,P<0.05),与肝纤维化无相关;PCⅢ和HA随肝纤维化程度而增高,在慢活肝、肝硬化及肝癌伴肝硬化组显著高于慢迁肝和正常对照组(P<0.01),肝硬化组PCⅢ和HA水平亦显著高于慢活肝组(P<0.05)。 结论 测定血清PCⅢ和HA水平对肝纤维化的诊断有重要意义。
Objective To investigate serological diagnosis of liver fibrosis. Methods Serum prolactin (PLD), procollagen Ⅲ (Ⅲ) and hyaluronic acid (HA) were measured in 30 normal subjects and 73 patients with various chronic liver diseases. Results The change of PLD activity was significantly associated with ALT (r = 0.4495, P <0.05), but not with liver fibrosis. PCⅢ and HA were increased with the degree of liver fibrosis, and significantly decreased in patients with chronic liver cancer, liver cirrhosis and hepatocellular carcinoma with cirrhosis (P <0.01). The levels of PC Ⅲ and HA in patients with cirrhosis were significantly higher than those in patients with chronic liver failure (P <0.05). Conclusion The determination of serum PCⅢ and HA levels is of great significance for the diagnosis of liver fibrosis.