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目的 探讨宫颈分泌物中磷酸化胰岛素样生长因子结合蛋白 1(IGFBP 1)对早产的预测价值。方法 选择 2 0 0 1年 1～ 12月在产科住院诊断为先兆早产的孕妇 90例 ,用分娩预测试纸检测宫颈分泌物中磷酸化IGFBP 1,并观察记录分娩情况。结果 检测阳性者 36例 ,1周内分娩率 5 0 % ,检测阴性者5 4例 ,1周内分娩率 7.4% ,两者差异显著 (P <0 .0 5 )。结论 应用分娩预测试纸检测宫颈分泌物中磷酸化IGFBP 1预测先兆早产孕妇 1周内早产危险增加
Objective To investigate the predictive value of phosphorylated insulin-like growth factor binding protein-1 (IGFBP 1) in cervical secretions for preterm labor. Methods Ninety pregnant women diagnosed as threatened premature labor in obstetrics and gynecology hospitalized from January to December 2001 were recruited. Pregnancy test strips were used to detect phosphorylated IGFBP 1 in cervical secretions, and records of delivery and delivery were observed. Results 36 cases were positive, the rate of delivery was 50% within 1 week, 54 cases were negative, 7.4% within 1 week, the difference was significant (P <0.05). Conclusions The use of prenatal test strips to detect phosphorylated IGFBP-1 in cervical secretions predicts an increased risk of preterm birth among preterm pregnant women within one week