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目的探讨益气温阳活血为法组方的对骨质疏松症的药效学实验研究。方法采用骨松I号胶囊治疗维甲酸诱导的骨质疏松症模型,并以为对照药物,观察实验大鼠的饮食情况、活动度、毛色情况,骨密度观察,血清钙、磷含量,血清碱性磷酸酶含量,尿羟脯氨酸/尿肌酐比值等指标。结果骨松I号胶囊不仅可显著改善实验大鼠的饮食情况、活动度、毛色,还可显著地改善骨密度观察,血清钙、磷含量,血清碱性磷酸酶含量,尿羟脯氨酸/尿肌酐比值等指标。结论骨松I号胶囊对维甲酸引起的实验性骨质疏松症均有明显的防治作用,其作用机制可能与骨松I号整体调节机体功能,提高机体抵抗力,抑制骨吸收,促进骨形成有关。
Objective To investigate the pharmacodynamics of osteoporosis treated with Yiqiyangyang Huoxue as a prescription. Methods Gusong I capsule was used to treat the model of osteoporosis induced by retinoic acid. The control drug was used to observe the diet, activity and color of the experimental rats. Bone mineral density observation, serum calcium, phosphorus content, serum alkaline Phosphatase content, urinary hydroxyproline / urinary creatinine ratio and other indicators. Results Gusong I capsule can not only improve the diet, activity, and coat color of the experimental rats, but also significantly improve the observation of bone mineral density. Serum calcium and phosphorus content, serum alkaline phosphatase, urinary hydroxyproline/ Urinary creatinine ratio and other indicators. Conclusion Gusong I capsule has obvious preventive and therapeutic effects on experimental osteoporosis induced by retinoic acid. The mechanism may be related to the overall regulation of body function of Gusong I, improve body resistance, inhibit bone resorption, and promote bone formation. related.