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目的对比分析甲泼尼龙琥珀酸钠与氢化可的松琥珀酸钠在中重度毛细支气管炎中的治疗效果。方法回顾性分析2009年8月至2014年8月收治的126例中重度毛细支气管炎患儿的临床资料,随机将其分为对照组与研究组,每组63例,对照组给予氢化可的松琥珀酸钠治疗,研究组给予甲泼尼龙琥珀酸钠治疗。经过治疗后,观察两组患者的呼吸频率、心率、肺部哮鸣音等临床症状,对比其治疗效果、吸氧时间以及住院时间等。结果研究组总有效率为96.8%,明显高于对照组(71.4%,P<0.01),且研究组患者的临床症状消失时间、住院时间与吸氧时间明显短于对照组,两组比较差异均有统计学意义(P<0.05)。结论甲泼尼龙琥珀酸钠用于治疗中重度毛细支气管炎可缩短治疗住院时间,临床疗效显著优于氢化可的松琥珀酸钠,值得推广应用。
Objective To compare the therapeutic effect of methylprednisolone sodium succinate and hydrocortisone sodium succinate in patients with moderate-severe bronchiolitis. Methods The clinical data of 126 children with moderate or severe bronchiolitis admitted from August 2009 to August 2014 were retrospectively analyzed. They were randomly divided into control group and study group, with 63 cases in each group. The control group was given hydrogenated Sodium succinate, the study group was given methylprednisolone sodium succinate treatment. After treatment, observe the clinical symptoms of respiratory rate, heart rate, lung wheeze and other two groups of patients, compared with the treatment effect, oxygen inhalation time and hospital stay. Results The total effective rate in study group was 96.8%, which was significantly higher than that in control group (71.4%, P <0.01). The disappearance time, hospital stay time and oxygen inhalation time of clinical symptoms in study group were significantly shorter than those in control group All were statistically significant (P <0.05). Conclusion The use of methylprednisolone succinate in the treatment of moderate-severe bronchiolitis can shorten the length of hospital stay. The clinical efficacy is significantly better than that of hydrocortisone sodium succinate, which is worthy of promotion and application.