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目的探讨丙型肝炎病毒抗体(抗-HCV)和丙型肝炎病毒核糖核酸(HCV-RNA)定量联合检测结果对丙型肝炎确诊的临床意义。方法对258例ELISA法检测的血清抗-HCV阳性丙型肝炎(HC)患者,同时采用PCR-荧光探针法检测其HCV-RNA含量。结果 258例抗-HCV阳性丙型肝炎患者中HCV-RNA阴性92例,占35.66%;17例HCV-RNA弱阳性,占6.59%;HCV-RNA阳性149例,即57.75%的HC患者存在病毒血症。结论 ELISA法联合检测抗-HCV和HCV-RNA有助于丙型肝炎确诊病毒血症以及监控HCV的感染,并及时进行抗病毒治疗。
Objective To investigate the clinical significance of the combined detection of hepatitis C virus (HCV) and hepatitis C virus (HCV) RNA in the diagnosis of hepatitis C (HCV). Methods 258 patients with serum anti-HCV positive hepatitis C (HC) detected by ELISA were assayed for HCV-RNA content by PCR-fluorescent probe. Results Among 258 anti-HCV positive hepatitis C patients, 92 were HCV-RNA negative (35.66%), 17 were HCV-RNA negative (6.59%), 149 were HCV RNA positive (57.75% Blood disorders. Conclusion The combination of ELISA and anti-HCV and HCV-RNA can be used to confirm the diagnosis of hepatitis C in viraemia and to monitor the infection of HCV, and timely anti-HCV treatment.