梯络龙(2.7-双[2-(二乙氨基)-乙氧基]-9-芴酮)用于治疗肿瘤(如黑色素瘤)、血小板减少性紫癜与一些病毒疾患,也试用于治疗矽肺。本文研究与比较了梯络龙(T)在大鼠、狗与人体内的代谢,离体大鼠肝脏灌流代谢,以及大鼠肝微粒体体外代谢的情况,以便从代谢角度为阐明T的毒性与为临床使用T提供依据。 Tiegoldong (2.7-bis [2- (diethylamino) -ethoxy] -9-fluorenone) is also used in the treatment of tumors such as melanoma, thrombocytopenic purpura and some viral conditions and also in the treatment of silicosis . In this paper, we studied and compared the metabolism of Tieluolong (T) in rats, dogs and humans, the perfused hepatic metabolism in rats and the in vitro metabolism of rat liver microsomes in order to elucidate the toxicity of T from the perspective of metabolism And provide the basis for the clinical use of T.