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分枝杆菌Hsp60可能在RA 的病因学中具有重要作用。RA 患者血清中分枝杆菌Hsp60的IgA 和IgG 抗体升高。患者血清中非半乳糖基化IgG 也较正常人明显升高并同分枝杆菌Hsp60抗体升高呈平行关系。RA 关节组织Hsp60的表达增强。T 细胞特别是γδT 细胞可能在RA_1的病变形成中起重要作用。
Mycobacterium Hsp60 may play an important role in the etiology of RA. IgA and IgG antibodies to Mycobacterium Hsp60 in serum of patients with RA are elevated. Serum non-galactosylated IgG was also significantly higher than normal and with mycobacterial Hsp60 antibody was paralleled. The expression of Hsp60 in RA joint tissue increased. T cells, especially γδ T cells, may play an important role in the pathogenesis of RA_1.