论文部分内容阅读
目的探讨胃癌组织中维生素D受体(VDR)的表达,并与癌旁正常胃黏膜组织比较。方法采用免疫组化方法,检测75例胃癌组织和癌旁正常胃黏膜组织中VDR表达。结果胃癌组织中VDR表达显著低于正常胃黏膜(P<0.05)。癌组织中VDR的表达在不同年龄、性别、TNM分期、组织学分型、浸润深度、淋巴结转移之间差异无统计学意义。VDR表达与癌组织分化程度有关,高、中、低分化3组VDR表达依次降低,且差异有统计学意义(P<0.05)。结论 VDR表达可以作为判断胃癌分化程度的依据之一。
Objective To investigate the expression of vitamin D receptor (VDR) in gastric cancer tissue and compare with normal gastric mucosa adjacent to cancer. Methods Immunohistochemical method was used to detect the expression of VDR in 75 cases of gastric cancer and adjacent normal gastric mucosa. Results The expression of VDR in gastric carcinoma was significantly lower than that in normal gastric mucosa (P <0.05). There was no significant difference in the expression of VDR in different age, sex, TNM stage, histological type, depth of invasion, lymph node metastasis. The expression of VDR was related to the degree of cancer differentiation. The expression of VDR in high, moderate and poorly differentiated 3 groups decreased in turn, and the difference was statistically significant (P <0.05). Conclusion VDR expression can be used as a basis for judging the degree of gastric cancer differentiation.