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[目的]观察丹参川芎嗪联合西药治疗慢性乙型肝炎疗效。[方法]使用随机平行对照方法,将120例住院患者按按病志号抽签方法简单随机分两组。对照组60例保肝对症治疗,甘草酸二胺,还原型谷胱甘肽等。治疗组60例丹参川芎嗪80mg+5%葡萄糖250m L,静滴,1次/d;西药治疗同对照组。连续治疗8周为1疗程。观测临床症状、血清透明质酸(HA)、Ⅲ型胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、层黏蛋白(LN)、谷丙转氨酶(ALT)、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效38例,有效20例,无效2例,总有效率96.67%。对照组显效30例,有效17例,无效13例,总有效率78.33%。治疗组疗效优于对照组(P<0.05)。血清肝纤维化指标治疗组改善优于对照组(P<0.05,P<0.01).[结论]丹参川芎嗪联合西药治疗慢性乙型肝炎,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of ligustrazine and western medicine on chronic hepatitis B. [Methods] Using randomized parallel control method, 120 inpatients were randomly divided into two groups randomly according to the method of lot drawing. Control group, 60 cases of symptomatic treatment of liver, glycyrrhizin diamine, reduced glutathione and so on. The treatment group, 60 cases of Salvia Ligustrazine 80mg + 5% glucose 250m L, intravenous infusion, 1 / d; western medicine treatment with the control group. Continuous treatment for 8 weeks for a course of treatment. Clinical symptoms, serum HA, PCⅢ, Ⅳ-C, LN, ALT and adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group markedly effective in 38 cases, effective in 20 cases, 2 cases, the total effective rate was 96.67%. The control group, markedly effective in 30 cases, effective in 17 cases, ineffective in 13 cases, the total effective rate was 78.33%. The treatment group was better than the control group (P <0.05). Serum fibrosis indicators of the treatment group improved better than the control group (P <0.05, P <0.01). [Conclusion] Salviae miltiorrhizae ligustrazine combined with Western medicine in the treatment of chronic hepatitis B, with satisfactory results, no serious adverse reactions, it is worth promoting.