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目的观察慢性低压缺氧对大鼠肺组织锌、铜、铁含量的影响。方法Ｗｉｓｔａｒ大鼠６０只，随机分成缺氧１０天组、缺氧２０天组和对照组。将两缺氧组大鼠放入人体低压舱内，上升到７０００ｍ高度，停留１．５ｈ，每天１次。用ＷＦＸ－Ⅱ型原子吸收分光光度计测定大鼠肺组织中锌、铜、铁的含量。结果慢性低压缺氧１０天组大鼠肺组织铁含量明显增高（Ｐ＜０．０５）；慢性低压缺氧２０天组大鼠肺组织中锌、铜、铁含量明显增高（Ｐ＜０．０５）。结论慢性低压缺氧时肺组织锌、铜、铁含量增高。推测这种变化可能是一种代偿性反应，对预防呼吸系统感染有利。
Objective To observe the effects of chronic hypobaric hypoxia on the contents of zinc, copper and iron in rat lungs. Methods Sixty Wistar rats were randomly divided into 10 days hypoxia group, 20 days hypoxia group and control group. The two hypoxia rats into the human body low pressure cabin, rose to 7000m height, stay 1.5h, 1 times a day. The contents of zinc, copper and iron in rat lung tissue were determined by WFX-Ⅱ atomic absorption spectrophotometer. Results The contents of iron in the lungs of rats in chronic hypobaric hypoxia 10-day group were significantly increased (P <0.05), while those in chronic hypobaric hypoxic 20-day groups were significantly increased (P <0.05 ). Conclusion Chronic hypobaric hypoxia increased the contents of zinc, copper and iron in lung tissue. It is speculated that this change may be a compensatory response that is good for preventing respiratory infections.