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【目的】 探讨营养不良性生长迟缓儿童血清胰岛素样生长因子 1(IGF 1)的变化情况及其与体格发育指标的关系。【方法】 采用放射免疫法测定 2 3例营养不良性生长迟缓儿童及 17例正常儿童血清IGF 1水平 ,并与体格发育指标及血锌进行相关分析。【结果】 营养不良性生长迟缓儿童血清IGF 1和血清锌水平均显著降低 (P <0 .0 0 1) ,血清IGF 1与SDSwt、SDSht、克托莱 (Qentelet)指数及血锌呈显著正相关。【结论】 营养不良性生长迟缓儿童血清IGF 1水平显著降低 ,其降低的程度与体格发育指标异常程度相关
【Objective】 To investigate the changes of serum insulin-like growth factor-1 (IGF-1) in children with malnutrition and their relationship with physical development. 【Methods】 Serum IGF 1 levels were measured by radioimmunoassay in 23 cases of poor-nutrition growth retardation children and 17 cases of normal children, and their correlations were analyzed with physical development indexes and blood zinc. 【Results】 Serum levels of IGF-1 and serum zinc were significantly decreased in children with poor-nutrition growth retardation (P <0.01). Serum IGF-1 and SDSwt, SDSht, Qentelet index and serum zinc were significantly positive Related. 【Conclusion】 The level of serum IGF 1 in children with retardation of nutrition is significantly lower, and the degree of depression is related to the abnormality of physical development