论文部分内容阅读
Bmi-1(B-cell specific moloney murine leukemiavirus insertion site 1,Bmi-1)基因是PcG(Polycomb group,PcG)家族核心成员之一,属于一种原癌基因。首次于1991年荷兰癌症中心在鼠淋巴瘤细胞中发现的,其在细胞生长、增殖和干细胞自我更新的调节中发挥重要作用。Bmi-1基因表达异常与人类多种肿瘤的发生、发展过程有关,其中就包括食管癌、胃癌等消化道肿瘤,并与肿瘤的转移和扩散相关,有望成为一种新的肿瘤分子标志物。本文就Bmi-1基因与消化道肿瘤关系的研究进展作一综述。
Bmi-1 (Bmi-1) is one of the core members of PcG (Polycomb group, PcG) family and belongs to a protooncogene. For the first time in 1991 the Dutch Cancer Center was found in murine lymphoma cells, which play an important role in the regulation of cell growth, proliferation and stem cell self-renewal. Abnormal expression of Bmi-1 is related to the occurrence and development of many human tumors, including esophageal cancer, gastric cancer and other gastrointestinal tumors, which are related to the metastasis and spread of tumors, and may be a new tumor molecular marker. This article reviews the research progress of the relationship between Bmi-1 gene and gastrointestinal tumors.