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据报道,挥发性亚硝胺在健康人的尿和大便中、在胃肠失调病人的胃内容物和个别人的血液中均有存在,这就提出了在人体内发生亚硝化作用的可能性。为了进一步证实二烃基亚硝胺在人血中的存在,作者对38名健康人(19男性,19女性)进行了血液抽样分析。受检者年龄范围为21～60岁,平均年龄38岁。全血样本中的挥发性亚硝胺用蒸馏法从已用碱处理过的血中提取,或使用不加热的Na_2SO_4和硅藻土(Celite)的柱色谱法提取,这两种方法所取得的量相似,并且都不引起人造物(artifacts)的形成。
It has been reported that volatile nitrosamines are present in the urine and stools of healthy people, in the stomach contents of patients with gastrointestinal disorders, and in the blood of individuals, suggesting the possibility of nitrosation in the human body . To further confirm the presence of dihydrocarbyl nitrosamines in human blood, the authors performed a blood sampling analysis of 38 healthy subjects (19 males and 19 females). The subjects ranged in age from 21 to 60 years, with an average age of 38 years. Volatile nitrosamines in whole blood samples were extracted by distillation from blood that had been treated with alkali or by column chromatography using unwarmed Na 2 SO 4 and Celite, both of which Similar in quantity, and do not cause the formation of artifacts.