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目的:研究注意缺陷多动障碍(ADHD)患者感觉门控缺陷的特征以及与ADHD症状的相关性。方法:研究组为符合DSM-IV诊断标准的混合型ADHD患者29例,对照组为年龄、性别匹配的正常儿童26名。采用听觉条件(S1)-测试刺激(S2)范式检测P50电位,计算S2与S1波幅比值(S2/S1),即P50比值作为感觉门控抑制功能指标,采用SNAP-IV评估ADHD注意缺陷和多动冲动症状。结果:ADHD组S1波幅低于正常对照组,S2波幅高于对照组,差异有统计学意义(P均<0.05),两组S1、S2潜伏期无明显差异(P>0.05);P50比值明显低于正常对照组(P<0.05)比较。P50比值与注意缺陷症状、多动冲动呈正相关(r=0.59,r=0.38)。结论:ADHD患者存在感觉门控异常,并与ADHD症状呈正相关,值得进一步探讨其在诊断与临床评估中的应用价值。
AIM: To investigate the characteristics of sensory gating defects and their association with ADHD symptoms in patients with attention deficit hyperactivity disorder (ADHD). Methods: The study group consisted of 29 patients with mixed ADHD who met DSM-IV diagnostic criteria. The control group consisted of 26 normal children with matched age and sex. P50 potentials were measured using auditory condition (S1) -test stimulus (S2) paradigm, and S2 / S1 amplitude ratio (S2 / S1) was calculated. P50 ratio was used as a measure of gating inhibition. SNAP-IV was used to assess ADHD attention deficit Dynamic impulse symptoms. Results: The amplitude of S1 in ADHD group was lower than that in normal control group, and the amplitude of S2 was higher than that in control group (P <0.05). There was no significant difference in S1, S2 latency between two groups (P> 0.05). Compared with normal control group (P <0.05). The P50 ratio was positively correlated with attention deficit hyperactivity disorder (r = 0.59, r = 0.38). Conclusion: There is a sensory gating abnormality in ADHD patients, which is positively correlated with the symptoms of ADHD, so it is worth further exploring its value in diagnosis and clinical evaluation.