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目的 研究医院感染 (NI)大肠杆菌 (E .coli)与医院环境E .coli之间的相关性 ,以了解NI病原菌来源。 方法 比较E .coli医院感染株 (院感株 )、社区感染株、环境株的耐药谱以及随机引物扩增多态性基因分型 (RAPD)型别之间的差异 ,判断三者之间的相关性。 结果 收集到E .coli院感株 5株 ,社区感染株 17株 ;1190份环境样中共分离到E .coli 72株 ,环境分离率为 6.0 5 %。耐药率、耐药谱与RAPD分型综合研究表明 :在外科院感株和环境株之间有相关性 ,E .coliNI主要是外源性感染 ;其它科室 ,从时间和空间上来看 ,院感株、社区感染株和环境株之间无相关性 ,E .coliNI以内源性感染为主。 结论 在E .coliNI中外源性和内源性途径均存在。
Objective To study the correlation between hospital infection (NI) E. coli and hospital environment E.coli to understand the origin of NI pathogens. Methods To compare the differences of drug resistance spectrum of E. Coli hospital isolates (susceptible strains), community infected strains and environmental strains and the random amplified polymorphic DNA (RAPD) genotypes between the three groups Relevance. Results Five isolates of E.coli and seventeen community-acquired isolates were collected. Of the 1190 environmental samples, 72 isolates of E.coli were isolated, with environmental isolation rate of 6.05%. Resistance rate, drug resistance spectrum and RAPD typing comprehensive study showed that: there is a correlation between the surgical hospital strains and environmental strains, E. coliNI is mainly exogenous infection; other departments, from the time and space point of view, the hospital There was no correlation between susceptible strains, community-infected strains and environmental strains, and E.coliNI was mainly endogenous infection. Conclusion Both exogenous and endogenous pathways exist in E.coliNI.