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目的探讨维吾尔族宫颈癌发生发展过程中半乳糖凝集素1(Galectin-1),层粘连蛋白(laminin,LN)的表达及意义。方法采用免疫组化S-P法检测Galectin-1,LN蛋白在慢性宫颈炎(20例)、CINⅠ(20例)、CINⅡ-Ⅲ(20例),宫颈鳞癌(40例)中的表达。结果 Galectin-1在宫颈慢性炎症组,CINⅠ组、CINⅡ-Ⅲ组和宫颈鳞癌中的表达呈上升趋势(P<0.05),LN在各组中的表达呈下降趋势(P<0.05);并且Galectin-1与LN呈负相关(P<0.05)。结论 Galectin-1表达上调可能是维吾尔族妇女宫颈鳞癌发生的分子事件;Galectin-1和LN在维族妇女宫颈癌发生发展中可能起协同作用。
Objective To investigate the expression and significance of Galectin-1 and laminin (LN) during the development of Uigur cervical cancer. Methods The expressions of Galectin-1 and LN in chronic cervicitis (20 cases), CINⅠ (20 cases), CINⅡ-Ⅲ (20 cases) and cervical squamous cell carcinoma (40 cases) were detected by immunohistochemical S-P method. Results The expression of Galectin-1 in cervical chronic inflammation group, CINⅠgroup, CINⅡ-Ⅲ group and cervical squamous cell carcinoma showed an upward trend (P <0.05). The expression of LN in each group showed a decreasing trend (P <0.05); Galectin-1 was negatively correlated with LN (P <0.05). Conclusions The upregulation of Galectin-1 may be a molecular event in Uigur women with cervical squamous cell carcinoma. Galectin-1 and LN may play synergistic roles in the development of cervical cancer in Uighur women.