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除鞣质是丹参注射液制剂工艺的主要关键,近几年研究甚多,其中以醇溶液调pH法简便易行,较为常用。但对该法除鞣质最佳醇浓度和pH值尚未见报导。本文为此作了初步研究,报导如下: 实验部分一、试剂及仪器丹参(南京市药材公司提供) 原儿茶醛AR 上海化学试剂厂 721分光光度计上海分析仪器厂双波长薄层扫描仪日本岛津CS—930型 0.13％,亚甲蓝水溶液缓冲溶液:Na_2HPO_4——KH_2PO_4系统pH5.6—8.0 二、测定液制备取丹参1800g加水煮二次(2小时,1.5小时),过滤煎液,浓缩至1200ml,平分成4份,加入95％乙醇使含醇量分别达到60％、70％、80％、85％。
In addition to tannins is the main key of the Danshen injection preparation process, there are many studies in recent years, of which the alcohol solution to adjust the pH method is simple and easy to use, and is more commonly used. However, the optimal alcohol concentration and pH value of tannins in this method have not been reported yet. This article made a preliminary study and reported as follows: Experimental part I. Reagents and instruments Danshen (provided by Nanjing medicinal herbs company) Protocatechuic aldehyde AR Shanghai Chemical Reagent Factory 721 spectrophotometer Shanghai Analytical Instrument Factory dual-wavelength thin-layer scanner Japan Shimadzu CS-930 type 0.13%, methylene blue solution buffer solution: Na_2HPO_4 - KH_2PO_4 system pH 5.6-8.0 Second, the preparation of the test solution to take Danshen 1800g boiled twice (2 hours, 1.5 hours), filter decoction, Concentrate to 1200ml and divide it into 4 parts. Add 95% ethanol to make the alcohol content reach 60%, 70%, 80% and 85% respectively.