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目的 :探讨通痹冲剂治疗类风湿性关节炎的药理作用机制。方法 :二甲苯所致小鼠耳廓炎症 ,醋酸所致小鼠腹腔毛细血管通透性及扭体反应 ,弗反 ( Freund’ s)完全佐剂诱发大鼠佐剂性关节炎 ( AA)等病理模型。结果 :通痹冲剂 1 .0 g/ kg、2 .0 g/ kg时均能显著抑制小鼠耳廓肿胀度和扭体反应并可抑制大鼠关节肿胀度。结论 :通痹冲剂具有良好的抗炎镇痛作用 ,对佐剂性关节炎具有明显的预防和治疗作用。
Objective: To investigate the pharmacological mechanism of Tongbai granule in the treatment of rheumatoid arthritis. Methods: Ear auricle inflammation induced by xylene, peritoneal capillary permeability and writhing induced by acetic acid in mice and adjuvant arthritis (AA) induced by Freund ’s complete adjuvant Pathological model. Results: Tongbi granule 1 .0 g / kg, 2.0 g / kg can significantly inhibit mouse auricle swelling and writhing reaction and can inhibit the degree of joint swelling in rats. Conclusion: Tongbi granule has good anti-inflammatory and analgesic effects and has obvious preventive and therapeutic effects on adjuvant arthritis.