目的探讨大剂量丙种球蛋白(IVIG)联合阿司匹林(ASP)治疗川崎病(KD)的临床效果。方法35例患儿分成治疗组20例联合应用大剂量丙种球蛋白及阿司匹林治疗,对照组15例单用阿司匹林治疗。结果治疗组在退热、黏膜充血、手足肿胀、颈淋巴结肿大消散及降低冠状动脉瘤的发生等方面与对照组比,差异有统计学意义。结论大剂量丙种球蛋白联合阿司匹林治疗川崎病疗效肯定,应尽早使用。 Objective To investigate the clinical effect of high-dose gamma globulin (IVIG) combined with aspirin (ASP) on Kawasaki disease (KD). Methods Totally 35 children were divided into treatment group (n = 20) and high-dose gamma-globulin (aspirin) and aspirin (n = 15). Fifteen patients in control group were treated with aspirin alone. Results Compared with the control group, the difference was statistically significant in the treatment group in terms of fever, mucosal congestion, swelling of hands and feet, dissipation of cervical lymph nodes and reduction of coronary aneurysm. Conclusion High-dose gamma globulin combined with aspirin treatment of Kawasaki disease affirmation should be used as soon as possible.