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硝苯吡啶(Nifedipine)是一种作用强而副作用轻的钙枯抗剂,是临床上治疗心绞痛、心功能不全、高血压和高血压急症的安全良效药物。近年来,发现它对许多疾病都呈现较好的治疗作用,现概述如下。一、支气管哮喘:硝苯吡啶能减轻或预防运动、冷空气、过敏原及组织胺等诱发的支气管痉挛。Corris(1983)用硝苯吡啶对8例运动性哮喘病人进行双盲观察,证实钙拮抗剂使运动性哮喘的严重程度明显减轻。Molho等(1987)作了进一步的研究,使用不同剂量的硝苯吡啶治疗哮喘,在服药后不同时间分别测定FVC及FEV_1,发现其对气道张力地影响与剂量有正相关系。据测对支气管平滑肌作用机理
Nifedipine is a powerful and side-effect calciflumetanide and is a safe and effective drug for the clinical treatment of angina pectoris, cardiac insufficiency, hypertension and hypertensive emergency. In recent years, it has found that it has a good therapeutic effect on many diseases and is summarized as follows. First, bronchial asthma: Nifedipine can reduce or prevent exercise, cold air, allergens and histamine induced bronchospasm. Corris (1983) double-blind observation of 8 cases of exercise-induced asthma patients with nifedipine, confirmed that calcium antagonists significantly reduce the severity of exercise-induced asthma. Molho et al. (1987) further studied the use of different doses of nifedipine in the treatment of asthma. FVC and FEV-1 were measured at different times after taking the drug. It was found that the effect on the airway tension was positively correlated with the dose. It is measured on the mechanism of bronchial smooth muscle