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目的:探究系统性红斑狼疮(Systemic Lupus Erythematosu,SLE)患者血脂异常的相关性。方法:选取148例SLE患者作为观察组,选取同期50例健康体检者作为对照组,观察比较两组患者血脂水平,包括总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、甘油三酯(TG)以及低密度脂蛋白-胆固醇(LDL-C)等。按照是否使用激素分为使用激素组(57例)和未使用激素组(91例),根据狼疮肾炎(LN)诊断标准分为LN组(69例)与非LN组(79例),比较使用激素者和未使用激素者、LN组和非LN组患者血脂水平。结果:SLE患者TC、TG及LDL-C水平均显著高于对照组,而HDL-C水平低于对照组。使用激素组患者TC、TG水平均高于未使用激素组,且HDL-C水平更低,差异具有统计学意义(P<0.05),但组间LDL-C水平比较差异无统计学意义(P>0.05)。结论:SLE患者血脂水平出现明显异常,较健康者更易发生粥样硬化,且长时间使用激素者与LN患者出现血脂异常的概率更高,因此SLE的血脂异常现象与使用激素、LN呈正相关。
Objective: To investigate the correlation of dyslipidemia in patients with systemic lupus erythematosus (SLE). Methods: A total of 148 patients with SLE were selected as the observation group and 50 healthy subjects were selected as the control group. The levels of serum lipids, including total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), glycerol Triester (TG) and low-density lipoprotein-cholesterol (LDL-C) and so on. The patients in LN group (n = 69) and non-LN group (n = 79) were divided into two groups according to whether the hormones were divided into hormone group (n = 57) and hormone group (n = 91) Hormone and non-hormone use, LN and non-LN group of patients with lipid levels. Results: The levels of TC, TG and LDL-C in patients with SLE were significantly higher than those in control group, while the levels of HDL-C were lower than those in control group. The levels of TC and TG in the hormone group were higher than those in the non-hormone group, and the HDL-C level was lower (P <0.05), but there was no significant difference between the groups > 0.05). CONCLUSIONS: Serum lipid levels in patients with SLE are significantly abnormal, more likely to be atherosclerosis than those in healthy individuals, and are more likely to develop dyslipidemia with prolonged use of hormones and LN. Therefore, there is a positive correlation between SLE dyslipidemia and the use of hormones and LN.