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目的了解新生儿脐血麻疹抗体水平的影响因素,为科学制定预防麻疹措施、降低小月龄婴儿麻疹发病提供依据。方法采用ELISA法检测100名妊娠母亲外周静脉血与所生新生儿脐带血麻疹Ig G抗体水平,对研究对象进行问卷调查。结果新生儿脐带血麻疹Ig G抗体阳性率为96.00%,保护率为54.00%,几何抗体平均浓度(GMC)为1 162.16 m IU/ml。新生儿的性别、产重、产次等因素对脐带血麻疹Ig G抗体水平无影响(P>0.05)。妊娠母亲有麻疹发病史组的新生儿脐带血麻疹Ig G抗体保护率及GMC均高于有接种疫苗史组及无接种疫苗且无麻疹发病史组,差异有统计学意义(P<0.05)。结论建议对育龄妇女进行麻疹疫苗复种,以提高新生儿胎传抗体水平,从而降低小月龄婴儿麻疹发病率。
Objective To understand the influencing factors of neonatal umbilical cord blood measles antibody level and to provide scientific basis for the prevention of measles and reduce the incidence of measles. Methods The peripheral venous blood of 100 pregnant women and the IgG antibody level of umbilical cord blood measles were detected by ELISA. The subjects were investigated by questionnaire. Results The positive rate of neonatal umbilical cord blood measles IgG antibody was 96.00%, the protective rate was 54.00%, and the geometric mean antibody concentration (GMC) was 1 162.16 m IU / ml. Neonatal gender, birth weight, parity and other factors had no effect on Ig G antibody level of umbilical cord blood measles (P> 0.05). The protection rate of neonatal umbilical cord blood measles Ig G antibody and the GMC in the pregnant women with the history of measles were higher than those in the vaccinated history group and the non-vaccinated and no measles history group (P <0.05). Conclusions It is suggested that multiple measles vaccination should be carried out on women of childbearing age to improve the level of fetal antibodies in newborns, so as to reduce the incidence of measles in small month-old babies.