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目的：证实甲砜霉素氯乙酸酯（α卤代羧酸酯类化合物）能与乌洛托品进行Ｄｅｌｅｐｉｎｅ反应，最终生成甲砜霉素甘氨酸酯盐酸盐。方法：利用电导率的方法测定Ｄｅｌｅｐｉｎｅ反应中间过程乌洛托品盐生成前后溶液的电导率的变化。结果：甲砜霉素氯乙酸酯与乌洛托品在乙腈溶液中能形成乌洛托品盐，且反应前后的电导率有明显的变化。结论：证实了甲砜霉素氯乙酸酯如同活性α卤代酮一样，能较好地进行Ｄｅｌｅｐｉｎｅ反应。
OBJECTIVE: To confirm that thiamphenicol chloroacetate (α-halocarboxylate) can deletion reaction with urotropin to produce thiamphenicol glycinate hydrochloride. Methods: The conductivity of the solution was measured before and after the formation of urotropine salt during the Delepine reaction. Results: Thiamphenicol chloroacetate and methenamine could form urotropine salt in acetonitrile solution with obvious changes before and after the reaction. Conclusion: It was confirmed that thiamphenicol chloroacetate, like active α-haloketone, can perform Delepine reaction well.