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以丙酮酸异烟酰腙作为配体与二苯基氧化锡反应,制得新配合物[Ph2Sn(C9H7N3O3)(H2O)]2。通过元素分析、红外光谱和核磁共振氢谱测试技术对其结构进行了表征,用X射线单晶衍射测定了化合物的晶体结构。该化合物晶体属正交晶系,空间群为P212121,晶胞参数a=1.1420(3)nm,b=1.1713(8)nm,c=3.520(2)nm,V=4.709(5)nm3,Z=4,μ=1.125mm-1,Dc=1.501Mg/m3,F(000)=2144,R=0.0745,wR=0.1704,GOF=1.015。测试结果表明,在配合物中锡原子处于七配位的五角双锥配位环境,配位原子分别来自1个三齿配体丙酮酸异烟酰腙负二价离子的2个O原子和1个N原子,1个水分子中的O原子,邻位配体中的1个O原子,以及来自于2个苯基的2个C原子,其中2个C原子占据了五角双锥的轴向位置。生物活性测试结果表明,化合物对MCF-7和WiDr均表现出较好的抑制作用。
The new complex [Ph2Sn (C9H7N3O3) (H2O)] 2 was prepared by the reaction of pyruvic acid isonicotinoyl hydrazone with diphenyltin oxide. Its structure was characterized by elemental analysis, IR and 1H NMR. The crystal structure of the compound was characterized by X-ray single crystal diffraction. The crystal of this compound belongs to the orthorhombic system with a space group of P212121 and unit cell parameters of a = 1.1420 (3) nm, b = 1.1713 (8) nm, c = 3.520 = 4, μ = 1.125 mm-1, Dc = 1.501 Mg / m3, F (000) = 2144, R = 0.0745, wR = 0.1704, GOF = 1.015. The results show that in the coordination complex, the tin atom is in the seven-coordinate pentagonal bipyramidal coordination environment, and the coordination atoms come from two ortho-divalent O atoms of 1-tridentate ligand pyruvate isonicotinyl hydrazone and 1 One N atom, one O atom in one water molecule, one O atom in the ortho ligand, and two C atoms from two phenyl groups, two of which occupy the pentagonal bipyramid in the axial direction position. Biological activity test results show that the compounds showed good inhibition of MCF-7 and WiDr.