通过EPR技术观察到一系列典型的烷基或甲氧基取代的苯基烷基酮ArCOR(Ar=2,5-二甲基苯基(1);2,5-二甲氧基苯基(2);4-叔丁基-2,5-二甲氧基苯基(3))与t-BuMgCl反应中形成的自由基阴离子中间体[ArC(R)OMgCl]。产物分析表明,反应主要生成还原产物[ArCH(R)OH]和1,2-加成产物[ArC(R)(t-Bu)OH]。降低溶剂极性及反应温度都有利于还原产物的生成。对上述反应的可能历程作了简单讨论。 A series of typical alkyl or methoxy-substituted phenyl alkyl ketones ArCOR (Ar = 2,5-dimethylphenyl (1); 2,5-dimethoxyphenyl 2); free radical anion intermediate [ArC (R) OMgCl] formed in the reaction of t-BuMgCl with 4-tert-butyl-2,5-dimethoxyphenyl (3) The product analysis shows that the reaction mainly produces the reduced product [ArCH (R) OH] and the 1,2-addition product [ArC (R) (t-Bu) OH]. Decreasing the polarity of the solvent and the reaction temperature are conducive to the formation of the reduced product. The possible course of the above reaction is briefly discussed.