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目的观察氧化苦参碱对于肾综合征出血热的治疗效果。方法将418例肾综合征出血热患者随机分为治疗组和对照组,治疗组应用氧化苦参碱静脉点滴,每日1次,每次600 mg,疗程为7 d,对照组应用传统的平衡盐疗法。观察两组患者的病情转归及并发症发生情况,动态检测患者血清中血清尿调蛋白(THP)和β_2微球蛋白(β_2M)的水平,同时观察血清白细胞介素15(IL-15)及可溶性细胞间黏附分子(slCAM-1)水平变化。结果氧化苦参碱治疗组患者病程缩短、预后改善,血清 THP 和β_2M 的水平均明显低于对照组,且治疗后血清 IL-15及 sICAM-1水平与对照组相比差异也有统计学意义。结论氧化苦参碱治疗肾综合征出血热疗效确切,值得临床进一步推广使用。
Objective To observe the therapeutic effect of oxymatrine on hemorrhagic fever with renal syndrome. Methods 418 patients with hemorrhagic fever with renal syndrome were randomly divided into treatment group and control group. The treatment group was given oxymatrine intravenously once a day for 600 mg for 7 days. The control group was given the traditional balance Salt therapy. Serum levels of urinary albumin (THP) and β_2-microglobulin (β_2M) were measured in patients with both disease and complications. The levels of serum interleukin 15 (IL-15) and Soluble intercellular adhesion molecule (slCAM-1) levels change. Results The course of oxymatrine treatment group was shortened, the prognosis was improved, the levels of serum THP and β_2M were significantly lower than the control group, and the serum IL-15 and sICAM-1 levels after treatment were also significantly different compared with the control group. Conclusion Oxymatrine treatment of renal syndrome hemorrhagic fever curative effect is worthy of clinical further promotion and use.