硫化氢及一氧化氮气体信号分子在高原高血压发病中的作用

来源 :高血压杂志 | 被引量 : 0次 | 上传用户:kongxianghua
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的探讨气体信号分子硫化氢(H2S)及一氧化氮(NO)在高原高血压的病理生理意义。方法平原体检正常者进入海拔5000m高原(1~3)月期间,在高原暴露时间、劳动强度及生活条件相同的施工群体中随机抽样127人。依血压变化将其分为高原高血压(Ⅰ~Ⅲ级)组78人(进一步分为收缩期高原高血压组与舒张期高原高血压组),高原正常血压组49人,采取肘静脉血,采用敏感硫电极法测定其H2S浓度,Griess法测定血清NO含量。结果高原高血压组、收缩期高原高血压组、舒张期高原高血压组的血清H2S与NO平均含量均显著增加,分别比正常血压组高34·5%,36·9%,31·7%(均P<0·001)与28·4%,33·1%,39·7%,(均P<0·05),尤以H2S更为突出;随着血压分级程度的升高H2S与NO血清含量相应增高,也以H2S更显著(R2=0·918);H2S与NO、舒张压间均有密切正相关关系及良好的拟和优度、与氧饱和度呈显著的负相关与拟和优度(R2=0·374,P=0·001)。结论H2S与NO的代谢失常可能参与了高原高血压发病过程。 Objective To investigate the pathophysiological significance of gas signaling molecules hydrogen sulfide (H2S) and nitric oxide (NO) in plateau hypertension. Methods A total of 127 normal people were enrolled in the construction community with the same exposure time, labor intensity and living conditions during the altitude of 5000m plateau (1-3 months). According to the change of blood pressure, it was divided into high altitude (grade Ⅰ ~ Ⅲ) group of 78 people (further divided into systolic hypertension group and diastolic high altitude hypertension group), plateau normal blood pressure group of 49 people, Sensitized sulfur electrode method was used to determine the concentration of H2S, and Griess method was used to determine the content of serum NO. Results The mean levels of serum H2S and NO in plateau hypertensive group, systolic plateau hypertensive group and diastolic plateau hypertensive group increased significantly, which were 34.5%, 36.9% and 31.7% higher than those in normal blood pressure group respectively (All P <0.001) and 28.4%, 33.1% and 39.7% respectively (all P <0.05), especially H2S. With the increase of blood pressure classification, H2S and The serum level of NO increased accordingly (R2 = 0. 918). There was a close positive correlation between H2S and NO and diastolic blood pressure and a good goodness of fit, which was negatively correlated with oxygen saturation Quasi goodness of fit (R2 = 0.374, P = 0.001). Conclusions The metabolic disorders of H2S and NO may be involved in the pathogenesis of high altitude hypertension.
其他文献
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
期刊
目的:观察不同浓度的白背叶根含药血清对脂多糖(lipopolysac-charide,LPS)诱导下RAW264.7细胞分泌的影响.方法:制作高、中、低浓度白背叶根含药血清,以CCK-8法检测不同浓度白
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
期刊
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
期刊
本文介绍可作抗体的寡核苷酸——Aptamer(暂译为适体)其制备过程无需动物或细胞,对检测的靶分子有严格的识别能力和反应特异性,具有反应条件的可修饰性和检测应用的广泛性,且
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
期刊
正常情况下,Fas系统涉及到组织细胞的生理性凋亡.Fas/Fas-L表达于淋巴细胞、粒细胞等免疫细胞上,介导了免疫调控和免疫病理,不同肿瘤组织细胞表达Fas/Fas-L水平不一致,不但影
阴茎癌前哨淋巴结(sentinel lymph node,SLN)活检术是一项阴茎癌准确分期的微创活检技术,可准确评估阴茎癌腹股沟淋巴结的病理状态,对于早期判断阴茎癌腹股沟淋巴结有无转移
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
期刊