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人类肿瘤的发生发展与细胞内基因组的变化有密切关系 ,癌基因的激活和抑癌基因的失活或缺失起了重要作用。近年来 ,关于肿瘤抑制基因的异常表达与肿瘤发生发展关系的研究已成为肿瘤分子生物学研究的热点问题之一。其中ｐ16基因是人类发现的第 1个直接参与细胞周期调节的抑癌基?
The occurrence and development of human tumors are closely related to the changes of the intracellular genome. The activation of oncogenes and the inactivation or deletion of tumor suppressor genes play an important role. In recent years, the study on the relationship between the abnormal expression of tumor suppressor genes and tumorigenesis has become one of the hot issues in molecular biology of tumors. Which p16 gene is the first human found that directly involved in cell cycle regulation of tumor suppressor?