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对２０例经血清病原学确诊的急性丙型肝炎肝穿病例，进行了临床和病理特征分析。２０例中１８例在发病前２０～１２０天内有手术输血史．临床症状、ＡＬＴ水平，与潜伏期及输血量无明显相关。病理改变主要为小叶及汇管区炎症，纤维化不明显。较特征的改变有：①以大泡脂变为特征的肝细胞“片状变性区”；②窦淋巴细胞渗出较显著，以Ｔ细胞为主；③坏死灶较小，局部炎细胞较多，嗜酸小体易见；④汇管区淋巴细胞聚集；⑤小胆管损伤。其中“片状变性区”及明显的窦淋巴细胞渗出，在病程１月内症状较重者更显著；汇管区淋巴细胞聚集及小胆管损伤与病程无明显相关，不宜作为慢性标志。
The clinical and pathological features of 20 cases of acute hepatitis C with liver pathology diagnosed by serum etiology were analyzed. Eighteen of 20 patients had a history of transfusions within 20 to 120 days before onset. Clinical symptoms, ALT levels, and latency and blood transfusion no significant correlation. Pathological changes are mainly lobular and portal inflammation, fibrosis is not obvious. More characteristic changes are: ① bulky lipid change characterized by “degeneration of liver cells”; ② sinusoidal exudation more significant to T cells; ③ smaller necrotic lesions, more local inflammatory cells , Eosinophilic easy to see; ④ portal area lymphocyte aggregation; ⑤ small bile duct injury. Among them, “flaky degeneration region” and obvious sinusoidal lymphocyte exudation were more significant in severe disease within 1 month of disease course. Lymphocyte aggregation and small bile duct injury in portal area had no significant correlation with the course of disease, and should not be used as chronic signs.