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结核分枝杆菌和宿主细胞的相互作用在很大程度上决定结核的结局, 自噬是巨噬细胞清除结核分枝杆菌的策略之一;结核分枝杆菌也进化出了一套自噬逃逸机制, 利于其在巨噬细胞内的生存.自噬通路调控是细胞自噬发挥其生物学功能的基础, 影响结核分枝杆菌和巨噬细胞的作用结局, 本文主要讲述结核分枝杆菌入侵机体后巨噬细胞相关自噬通路调控以及结核分枝杆菌自噬抑制机制, 为寻找防止结核病的新靶点奠定基础.“,”To a large extent, interaction between Mycobacterium tuberculosis and macrophages determines the outcome of tuberculosis.One of the strategies for macrophages to defend against M.tuberculosisis autophagy.M.tuberculosis is killed by macrophages via autophagy, but M.tuberculosis has also evolved a set of mechanisms to evade autophagy, allowing M.tuberculosis to survive in macrophages.Autophagy is regulated by signaling pathways, and autophagy affects the outcome of interaction between M.tuberculosis and macrophages.This article mainly discusses the mechanisms regulating autophagy in macrophages and the mechanisms by which M.tuberculosisinhibits autophagy.Autophagy can be induced by M.tuberculosis cell wall antigens, lipoproteins, DNA, and other substances.M.tuberculosis can indirectly inhibit autophagy by regulating miRNAs.M.tuberculosis can also directly inhibit autophagy via its proteins.This information lays the foundation for identification of new targets to prevent tuberculosis.