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目的:探讨口服小剂量胺碘酮对老年心律失常患者甲状腺功能的作用和影响。方法:回顾性分析老年器质性心脏病心律失常患者68例,记录胺碘酮治疗方案与疗效、甲状腺变化及随访干预措施情况。结果:老年人服用胺碘酮引起甲状腺疾病发生率为31.8%(22/68),以甲状腺功能减退25.7%(18/68)为主,大致为甲状腺功能亢进(6.1%,4/68)的4倍。采用小剂量胺碘酮方案出现的甲状腺功能紊乱多数经过减量或停药逆转或恢复。结论:老年人服用胺碘酮甲状腺功能紊乱发生率高,但临床表现不典型,应更密切地监测甲状腺功能;甲状腺功能紊乱经胺碘酮及时减量或停药等措施多能逆转或恢复。
Objective: To investigate the effect and effect of oral low dose amiodarone on thyroid function in elderly patients with arrhythmia. Methods: A retrospective analysis of 68 elderly patients with organic heart disease arrhythmia, recording the treatment of amiodarone and efficacy, thyroid changes and follow-up interventions. Results: The incidence of thyroid disease in elderly patients was 31.8% (22/68) with amiodarone, and 25.7% (18/68) with hypothyroidism. The prevalence of thyroid disease was about 6.1% (4/68) of patients with hyperthyroidism 4 times. The use of small doses of amiodarone regimen appear most of the thyroid dysfunction reversal or recovery after reduction or withdrawal. Conclusions: The incidence of thyroid dysfunction in elderly patients is high, but the clinical manifestations are not typical. Thyroid function should be monitored more closely. Thyroid dysfunction can be reversed or recovered by amiodarone administration in a timely manner.