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目的提高对假性甲状旁腺功能减退症的诊治率。方法回顾性分析我院1990年1月-2008年8月入院的10例假性甲状旁腺功能减退症患者的临床资料。结果10例患者就诊时病程长短不一(3d~9年),发病年龄轻,均有手足搐溺、多次癫痫发作病史,伴有四肢乏力。实验室检查提示低血钙、高血磷、高甲状旁腺激素血症。6例手足及全身骨骼平片提示异常,9例头颅CT提示多发颅内钙化灶,2例伴有AHO躯体畸形,4例合并甲状腺功能异常,2例合并低血钾。结论对于有手足搐溺、癫痫发作等病史的患者要进一步检查血钙、血磷及甲状旁腺激素水平,行头颅CT。用钙剂、维生素D能控制假性甲状旁腺功能减退症的症状。注意监测甲状腺功能,及时发现潜在的甲状腺功能异常,进行系统治疗。
Objective To improve the diagnosis and treatment of pseudo-hypoparathyroidism. Methods The clinical data of 10 patients with pseudo-hypoparathyroidism admitted to our hospital from January 1990 to August 2008 were retrospectively analyzed. Results The duration of the 10 cases was different (3d ~ 9 years), the age of onset was light, all had hand-foot and hand-twitch, history of multiple epileptic seizures, accompanied by limb weakness. Laboratory tests suggest hypocalcemia, hyperphosphatemia, hyperparathyroid hormone hyperlipidemia. 6 cases of hand, foot and general bone showed abnormalities, 9 cases of cranial CT suggestive of intracranial calcification, 2 cases of somatic deformity with AHO, 4 cases of abnormal thyroid function, and 2 cases of hypokalemia. Conclusion For patients with hand, foot and flirting, epileptic seizures and other patients to further check serum calcium, phosphorus and parathyroid hormone levels, line head CT. With calcium, vitamin D can control the symptoms of pseudo-hypoparathyroidism. Pay attention to monitoring thyroid function, timely detection of potential thyroid dysfunction, systematic treatment.