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目的探讨前庭诱发肌源性电位(vestibular evokedmyogenic potentials,VEMPs)在多发性硬化(multiple sclerosis,MS)中的诊断价值。方法用短声刺激记录34例MS患者(核磁共振成像脑干和(或)小脑是否出现病灶,分为两组,显示受损者组19例,标记为MRI阳性组;未显示受损者组15例,标记为MRI阴性组)和34例健康对照组的VEMPs的潜伏期,34例MS患者均做核磁共振成像。结果 34例MS患者中17例出现异常VEMP。其中,11例的一侧耳P13潜伏期延长,3例两侧P13潜伏期均延长。3例单侧未引出VEMP。MS组和对照组相比,平均p13潜伏期显著延长(右侧P<0.05,左侧P<0.05),N23潜伏期未见明显延长。MRI检出的阳性率及VEMPs的阳性率,二者无相关性。结论 VEMPs可作为判定MS前庭脊髓通路脱髓鞘病变的辅助检查工具。
Objective To investigate the diagnostic value of vestibular evoked myogenic potentials (VEMPs) in multiple sclerosis (MS). Methods Thirty-four MS patients were recorded with short-sonic stimulation (MRI), and the lesions were divided into two groups, which showed that 19 cases were damaged and marked as MRI positive group; 15 cases, marked as MRI-negative group) and 34 healthy control group of VEMPs incubation period, 34 cases of patients with MS were done magnetic resonance imaging. Results Among 34 MS patients, 17 cases had abnormal VEMP. Among them, the latency of P13 on the one side of 11 cases was prolonged, and the latency of P13 on both sides of the three cases was prolonged. 3 cases unilateral induced VEMP. Compared with the control group, the average p13 latency was significantly longer in MS group (P <0.05 on the right and P <0.05 on the left), and no significant prolongation of N23 latency. There was no correlation between the positive rate of MRI and the positive rate of VEMPs. Conclusion VEMPs can be used as an auxiliary diagnostic tool to determine demyelinating lesions in the vestibular spinal cord of MS.