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时间药理学是一门新兴起的应用科学,已经证明许多药物具有明显的时间活性,开展时间药理学的研究意义决不亚于寻找新药。本文介绍了常用小鼠ICR、BALB/C、615、C57BL/6和昆明种上午8点至下午8点外周血白细胞数节律变化规律,初步报道白细胞数变化二端值区域给药对阿霉素,米托蒽醌和阿克拉霉素三种抗肿瘤抗生素活性的影响。小鼠外周血白细胞数节律变化的基本模式据我们观察,小鼠外周血白细胞数(下称外周白)节律变化大致为外周模式(见附图中8:00～20:00)特点是上午高下午低。8:00
Time pharmacology is a newly emerging applied science and it has been proved that many drugs have obvious time activity. The research significance of time pharmacology is no less than finding new drugs. This article describes the rhythm of peripheral blood leukocyte counts in commonly used mouse ICR, BALB/C, 615, C57BL/6 and Kunming species from 8 am to 8 pm, and preliminary reports of changes in the number of leukocytes in the two-terminal region administered doxorubicin. , Mitoxantrone and aclamycin have three antitumor antibiotic activities. Basic patterns of rhythm changes in peripheral blood leukocytes in mice According to our observations, the peripheral blood leukocyte count (hereinafter referred to as peripheral white) rhythm is roughly the peripheral pattern (see 8:00 to 20:00 in the figure). Low in the afternoon. 8:00