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采用 EIA、PCR技术对急、慢性丙肝患者血清标本进行乙型肝炎病毒标志物、丙型肝炎不同功能区抗体和 HBVDNA、HCVRNA检测。结果 :排除甲、戊型肝炎的急、慢性丙肝的乙肝感染率为74 .67%和 59.0 9%均以 HBc Ab和 HBs Ab为主 ,其他标志物很少出现 ,有乙肝感染的丙肝 AL T值较高。HBVDNA检出率较低 ,且与 HCVRNA极少同时检出 ;急、慢性丙肝 HCVRNA检出率有乙肝感染时明显偏低。有乙肝感染时急性丙肝中 E、NS4— 5区抗体检出率明显低于慢性丙肝和无乙肝感染的急性丙肝。认为急性丙肝易受乙肝感染 ,受乙肝感染的急性丙肝 HCV抗 E、NS4— 5区抗体的产生受到抑制 ,乙、丙肝病毒之间有相互抑制现象 ,二者重叠感染可加重肝损害 ;有 HBVDNA检出者主要以乙肝感染为主
Serum samples of acute and chronic hepatitis C patients were tested for hepatitis B virus (HBV) markers, antibodies to different functional regions of hepatitis C and HBVDNA and HCV RNA using EIA and PCR techniques. Results: The rates of hepatitis B infection in acute and chronic hepatitis C patients with hepatitis A and hepatitis E were 74.67% and 59.0%, respectively. HBc Ab and HBs Ab were the main symptoms. Other markers of hepatitis C infection such as ALT Higher value. HBVDNA detection rate is low, and with very few simultaneous detection of HCVRNA; acute and chronic hepatitis C HCVRNA detection rate of hepatitis B infection was significantly lower. With hepatitis B infection in acute hepatitis C in E, NS4-zone antibody detection rate was significantly lower than those of chronic hepatitis C and hepatitis B-free acute hepatitis. It is considered that acute hepatitis C is susceptible to hepatitis B infection. The production of anti-hepatitis C, anti-NS, and anti-NS4 antibodies of hepatitis C infected patients is inhibited. Mutual inhibition between hepatitis B and C viruses can aggravate liver damage. The main detection of hepatitis B infection