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目的:探讨并分析抗菌药物合理应用中临床药师的干预作用。方法:选取在我院行抗菌药物不合理应用的116例病例为研究对象,统计临床药师干预后抗菌药物应用采纳率,并分析临床药师参与抗菌药物合理应用的干预作用。结果:经临床药师干预后,未做病原学培养、溶媒选择不当、用法及剂量不当、无指征联合用药、围手术期预防用药不合理等问题提出干预措施并予以采纳,总采纳率为84.48%;采纳后患者恢复情况得以改善,调整抗菌药物用药的感染性疾病患者中痊愈率高于未调整的,非感染性患者抗菌药物调整后感染率低于未调整的。结论:抗菌药物合理应用中临床药师的干预作用显著。
Objective: To explore and analyze the intervention of clinical pharmacists in rational use of antimicrobial agents. Methods: One hundred and sixty-six cases of unreasonable use of antimicrobial agents in our hospital were selected as the study objects. The adoption rate of antimicrobial agents after the intervention of clinical pharmacists was calculated and the intervention effect of clinical pharmacists participating in rational use of antimicrobial agents was analyzed. Results: After the intervention of clinical pharmacists, the interventions were put forward without adopting etiological culture, improper solvent selection, improper usage and dosage, no indications of combined medication and irrational perioperative prophylaxis. The total adoption rate was 84.48 %. After the adoption, the recovery of patients was improved. The cure rate of patients with infectious diseases adjusted for antibacterial drugs was higher than that of unadjusted ones. The adjusted infection rate of antibacterials in non-infected patients was lower than that of unadjusted ones. Conclusion: The clinical pharmacist intervention in the rational use of antimicrobial agents is significant.