论文部分内容阅读
目的:研究隔山消及其不同炮制品的抗炎作用及机制。方法:采用二甲苯致小鼠耳廓肿胀、角叉菜胶致小鼠足肿胀和醋酸致小鼠腹腔毛细血管通透性试验观察其抗炎作用,测定对炎症渗出液中前列腺素E2(PGE2)以及血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、过氧化氢酶(CAT)和一氧化氮(NO)的影响。结果:隔山消生品及炮制品(24、和8g/kg)对小鼠耳廓肿胀及足肿胀均有明显的抑制作用,并可显著抑制醋酸致小鼠腹腔毛细血通透性增加。能够明显降低炎症渗出液中PGE2和血清中MDA、NO含量,明显提高小鼠血清SOD和CAT活力。结论:隔山消及两种炮制品均有一定的抗炎作用,两种炮制品的抗炎效果比生品有所增强。抗炎作用机制可能与其抑制PGE2、NO等炎症介质生成,抑制脂质过氧化、增强自由基清除能力有关。
Objective: To study the anti-inflammatory effect and mechanism of Jiashanxiao and its different processed products. Methods: The anti-inflammatory effects of xylene-induced mouse ear swelling, carrageenan-induced foot swelling and acetic acid-induced peritoneal capillary permeability in mice were observed. The levels of prostaglandin E2 PGE2 and serum superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT) and nitric oxide (NO) were measured. Results: Geosyntrex malt extract and processed products (24, and 8g / kg) had obvious inhibitory effects on mouse ear auricle swelling and foot swelling, and significantly inhibited the increase of peritoneal capillary permeability of mice induced by acetic acid. Can significantly reduce inflammatory exudate PGE2 and serum MDA, NO content, significantly increased serum SOD and CAT activity. Conclusion: Gushanxian and the two processed products have certain anti-inflammatory effects, the anti-inflammatory effects of the two processed products are enhanced than the raw products. Anti-inflammatory mechanism may be related to its inhibition of PGE2, NO and other inflammatory mediators, inhibition of lipid peroxidation, enhanced free radical scavenging capacity.