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采用间接免疫荧光技术检测了22例晚期血吸虫病患者肝脏内γ干扰素(IFN-γ)的分布。发现晚期血吸虫病患者肝内IFN-γ主要分布于汇管区虫卵肉芽肿内、肉芽肿外层和虫卵周围。大量纤维结缔组织增生的汇管区基本无或有很少量的IFN-γ存在.提示IFN-γ可能在血吸虫病的肝脏免疫病理中起重要作用。
Indirect immunofluorescence was used to detect the distribution of IFN-γ in the liver of 22 advanced schistosomiasis patients. Found in patients with advanced schistosomiasis IFN-γ liver are mainly distributed in the portal area within the egg granuloma, granuloma and the outer layer of eggs around. There was almost no or very small amount of IFN-γ in the portal area of a large number of fibrous connective tissue hyperplasia, suggesting that IFN-γ may play an important role in the immunopathology of liver in schistosomiasis.