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硝苯地平是常用的治疗心绞痛和高血压的钙通道阻滞剂,研究表明,口服硝苯地平后需经历广泛的首过效应,且证实细胞色素P-450系统可以促使硝苯地平代谢。由于受试者内和受试者间的系统差异,为了保持有效的血药浓度水平,必须按照硝苯地平的治疗剂量方案给药。当其与能诱?
Nifedipine is a commonly used calcium channel blocker for angina pectoris and hypertension. Studies have shown that oral nifedipine undergoes extensive first-pass effects and confirms that the cytochrome P-450 system can promote nifedipine metabolism. Due to the systematic differences between subjects and subjects, in order to maintain an effective plasma concentration level, it has to be administered in accordance with the nifedipine therapeutic dosage regimen. When can it be lured?