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1987~1993年检测了AFP病例147名,其中属广州市本地患者86例。通过病毒分离鉴定,血清学检查和病毒抗原表位分析揭示了广州地区AFP的病原学具有四个特点:(1)除了PV_(1-3)型之外,还有CoxA9,CoxB3、5,ECHO7、12、13、18,以及一些未定型的非PV肠道病毒;(2)脊灰病例与非脊灰病例之比下降(0.87:1);(3)从广州市脊灰病例所分离的病毒型别及抗原性质已由PV_1型野病毒为主,动态地转变为PV_2型类疫苗株为主。从1992年开始已不能从病人分离到野病毒株;(4)输入脊灰病例已超过本地病例(47:40),输入脊灰仍然是以PV_1型为主。
From 1987 to 1993, 147 AFP cases were detected, of which 86 were local patients in Guangzhou. Isolation and identification of viruses, serological tests and analysis of epitopes revealed that there are four characteristics of AFP etiology in Guangzhou: (1) In addition to PV_ (1-3), CoxA9, CoxB3,5, ECHO7 , 12,13,18, and some non-typed non-PV enterovirus; (2) the ratio of polio cases to non-polio cases decreased (0.87: 1); (3) The type of virus and antigenic nature of the isolate have been mainly dominated by PV_1 type wild-type virus and dynamically transformed into PV-2 type vaccine strains. No wild-type isolates have been isolated from the patient since 1992; (4) polio cases have been imported more than local cases (47:40), polio inputs are still predominantly PV_1.