采用家兔给予高脂饲料建立动脉粥样硬化模型 ,然后给予心复宁 V号 (XFN- V)方予以治疗。通过血情总胆固醇、甘油三酯、高密度和低密度脂蛋白胆固醇、一氧化氮、血浆内皮素等指标观察 ,发现心复宁 V号方能降低血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇和血浆内皮素 ,升高高密度脂蛋白及一氧化氮 ,说明该方可通过调整脂质代谢 ,保护血管内皮 ,抑制动脉粥样硬化的发生和发展 Rabbits were given high-fat diet to establish atherosclerosis model, and then given Xinfuning V (XFN-V) to be treated. Through observations of total cholesterol, triglyceride, high-density and low-density lipoprotein cholesterol, nitric oxide, and plasma endothelin, it was found that Xinfuning V can lower serum total cholesterol, triglycerides, and low-density lipids. Protein cholesterol and plasma endothelin increase high-density lipoprotein and nitric oxide, indicating that this party can regulate lipid metabolism, protect the vascular endothelium, and inhibit the occurrence and development of atherosclerosis.