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目的探讨内皮素（ＥＴ）和血管紧张素Ⅱ（ＡⅡ）在脑梗塞中的作用及相互关系。方法应用放射免疫分析法同步测定３０例脑梗塞患者和３０例正常对照者血浆ＥＴ和ＡⅡ含量。结果脑梗塞急性期血浆ＥＴ和ＡⅡ含量均较正常对照组显著升高（Ｐ均＜０．０１），且中－重度脑梗塞组两者均显著高于轻度组（Ｐ均＜０．０１）。急性期血浆ＥＴ与ＡⅡ呈显著正相关（ｒ＝０．７０３３，Ｐ＜０．０１），恢复期（ｒ＝０．２４６５，Ｐ＞０．０５）和正常对照组（ｒ＝０．１８３７，Ｐ＞０．０５）无显著相关。结论脑梗塞时血浆ＥＴ和ＡⅡ增高并与病情严重程度相一致。内源性ＥＴ与ＡⅡ具有正反馈调节关系，两者相互作用可能在脑梗塞发病和进展过程中起重要作用
Objective To investigate the role and relationship of endothelin (ET) and angiotensin Ⅱ (AⅡ) in cerebral infarction. Methods Thirty patients with cerebral infarction and 30 normal controls were measured by radioimmunoassay simultaneously. Results The levels of plasma ET and AⅡ in acute stage of cerebral infarction were significantly higher than those in normal control group (all P <0.01), and those in moderate-severe cerebral infarction group were significantly higher than those in mild group (P <0.01) ). Acute phase of plasma ET and A Ⅱ was positively correlated (r = 0.7033, P <0.01), recovery (r = 0.2465, P> 0.05) and normal control group P> 0.05) no significant correlation. Conclusions Plasma ET and AII are increased in patients with cerebral infarction and consistent with the severity of the disease. Endogenous ET and A Ⅱ have a positive feedback regulation, the interaction between the two may play an important role in the pathogenesis and progression of cerebral infarction