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目的探讨血清癌抗原125(CA125)和人附睾蛋白4(HE4)联合盆腔磁共振成像(MR)检查在子宫内膜癌中的临床价值。方法选取该院收治的子宫内膜病变患者96例,分为子宫内膜癌组56例,子宫内膜不典型增生组40例;另选取同期因子宫肌瘤切除子宫的增生期和分泌期子宫内膜组20例为对照组。检测3组的血清CA125和HE4水平,并行盆腔MR检查,对比三者单独或联合检查的灵敏度及特异度。结果子宫内膜癌组血清CA125和HE4水平高于子宫内膜不典型增生组和对照组,子宫内膜不典型增生组血清CA125和HE4水平高于对照组,晚期子宫内膜癌组的血清CA125和HE4水平高于早期子宫内膜癌组,差异均有统计学意义(P<0.05)。CA125、HE4联合盆腔MR检查对子宫内膜癌诊断的灵敏度、特异度及准确性均高于其他指标,差异有统计学意义(P<0.05)。结论血清CA125和HE4是评估子宫内膜癌病情进展情况的重要指标,CA125和HE4联合盆腔MR检查可提高子宫内膜癌诊断的灵敏度和特异性,具有重要的临床参考价值。
Objective To investigate the clinical value of serum tumor antigen 125 (CA125) and human epididymal protein 4 (HE4) combined with pelvic MR imaging in endometrial carcinoma. Methods 96 patients with endometrial lesions treated in this hospital were divided into 56 cases of endometrial cancer group and 40 cases of endometrial dysplasia group. The other cases were selected for uterine myometrial hyperplasia and secretory uterus Intimal group of 20 cases as control group. Serum levels of CA125 and HE4 in the three groups were detected, and pelvic MR examination was performed to compare the sensitivity and specificity of the three alone or in combination. Results The levels of serum CA125 and HE4 in endometrial carcinoma group were higher than those in atypical hyperplasia group and control group. The levels of serum CA125 and HE4 in endometrial dysplasia group were higher than those in control group. The levels of serum CA125 in advanced endometrial carcinoma group And HE4 levels were higher than those in early endometrial cancer group (P <0.05). The sensitivity, specificity and accuracy of CA125 and HE4 combined with pelvic MR examination in the diagnosis of endometrial cancer were higher than those of other indexes, the difference was statistically significant (P <0.05). Conclusions Serum CA125 and HE4 are important indexes for evaluating the progress of endometrial carcinoma. The combination of CA125 and HE4 in pelvic MR can improve the sensitivity and specificity of endometrial carcinoma diagnosis and has important clinical reference value.