目的:研制一种单向缓释口腔溃疡散Ⅱ号双层膜,延长口腔溃疡散作用时间。方法:用聚乙烯醇、羧甲基纤维素钠作成膜材料,将口腔溃疡散Ⅱ号制成双层膜,观察其口腔粘附时间和对实验性口腔溃疡的治疗作用。结果:口腔溃疡散Ⅱ号双层膜的口腔粘附时间长,对实验性口腔溃疡有较好的治疗作用。结论:口腔溃疡散Ⅱ号双层膜克服了口腔溃疡散Ⅱ号作用时间短的不足,有较好的临床应用前景。 OBJECTIVE: To develop a one-way sustained release oral ulcers II double-layered membrane to prolong the time of oral ulcer dispersion. METHODS: Polyethlenol and sodium carboxymethyl cellulose were used as film-forming materials to make oral ulcer II a bilayer membrane. The oral adhesion time and therapeutic effect on experimental oral ulcers were observed. RESULTS: The oral adhesive time of Oral Ulcer Powder II was long, and it had a good therapeutic effect on experimental oral ulcers. Conclusion: The oral ulcer ulcer II double film overcomes the shortcomings of oral ulcers II and has a good clinical application prospect.